Ether biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ether biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, NAPG, and KIF14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ether biosynthetic process activity versus PLA2G4A in LUAD (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLA2G4A →	+1.943	+0.251	<.001	<.001	3	5
UCEC	NAPG →	+0.417	+0.288	<.001	<.001	3	4
LUAD	KIF14 →	+0.757	+0.119	<.001	.002	3	4
BRCA	EIF5AP4 →	+1.428	+0.595	.001	.006	3	4
LUAD	CEROX1 →	-0.288	-0.123	.003	.001	3	4
PDAC	MAPKAPK2 →	+0.210	+0.165	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901503 vs PLA2G4A — LUAD

Explore this scatter interactively →