Ether biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ether biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTCD, AMPD3, and PTPN13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSTCD grouped by Ether biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSTCD →	+0.778	+1.112	.003	.001	3	4
LIVER	AMPD3 →	-1.796	-1.771	.008	<.001	3	4
SKIN	PTPN13 →	+0.681	+0.993	.009	.004	3	4
UPPER_AERODIGESTIVE_TRACT	SYCE3 →	-0.651	-1.443	.001	<.001	3	4
LUNG_NSCLC_LUSC	FANCD2OS →	+0.218	+1.280	.003	.003	3	3
LUNG_NSCLC_LUSC	RBPMS2 →	+2.323	+1.347	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSTCD by Ether biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →