Regulation of lymphangiogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of lymphangiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPG2, C1QA, and FSCN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphangiogenesis activity versus HSPG2 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HSPG2 →	+0.519	+0.113	<.001	<.001	3	8
OV	C1QA →	+0.683	+0.086	.001	.001	3	7
OV	FSCN1 →	+0.523	+0.071	.002	.003	3	7
LSCC	RASA3 →	+0.336	+0.093	<.001	<.001	3	7
COAD	RCN3 →	+0.628	+0.074	<.001	<.001	3	6
BRCA	RSU1 →	+0.351	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901490 vs HSPG2 — LSCC

Explore this scatter interactively →