Regulation of tetrapyrrole metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of tetrapyrrole metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHEK2, RPP40, and ASNS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tetrapyrrole metabolic process activity versus CHEK2 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHEK2 →	+0.536	+0.067	<.001	<.001	3	6
LSCC	RPP40 →	+0.341	+0.064	<.001	<.001	3	5
BRCA	ASNS →	+0.606	+0.034	<.001	<.001	3	5
LUAD	XPO5 →	+0.468	+0.049	<.001	.001	3	5
BRCA	YME1L1 →	+0.265	+0.033	.001	.003	3	5
LSCC	CMSS1 →	+0.553	+0.040	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901401 vs CHEK2 — LSCC

Explore this scatter interactively →