Regulation of tetrapyrrole metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AW, BACH1-AS1, and ISM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tetrapyrrole metabolic process activity versus H2AW in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	H2AW →	+0.857	+0.149	<.001	<.001	3	3
LUAD	BACH1-AS1 →	-0.369	-0.153	.008	.002	3	3
PDAC	ISM1 →	-0.913	-0.123	<.001	<.001	3	3
PDAC	TTC23 →	-0.254	-0.096	.009	.007	3	3
PDAC	PDE1A →	-0.564	-0.137	<.001	<.001	3	3
PDAC	CNRIP1 →	-0.447	-0.133	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901401 vs H2AW — LUAD

Explore this scatter interactively →