Regulation of tetrapyrrole metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of tetrapyrrole metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABCB10, AFG3L2, and SIK2_S576, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tetrapyrrole metabolic process activity versus ABCB10 in PDAC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ABCB10 →	+0.689	+0.190	<.001	<.001	3	7
PDAC	AFG3L2 →	+0.353	+0.100	<.001	<.001	3	4
OV	SIK2_S576 →	+0.866	+0.159	<.001	<.001	2	4
PDAC	SMG7 →	+0.279	+0.137	<.001	<.001	3	3
PDAC	AIP →	-0.213	-0.096	<.001	<.001	3	3
UCEC	MTDH_S426 →	+0.441	+0.241	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901401 vs ABCB10 — PDAC

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