Regulation of tetrapyrrole metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANK3, LATS1, and VCAM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PANK3 grouped by Regulation of tetrapyrrole metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PANK3 →	-0.791	-0.155	.002	.005	3	4
CNS	LATS1 →	-0.467	-0.216	<.001	<.001	3	4
KIDNEY	VCAM1 →	+3.160	+0.174	<.001	.001	3	3
KIDNEY	CYB5R4 →	-0.875	-0.187	<.001	<.001	3	3
LIVER	GFER →	+0.578	+0.282	.001	.004	3	3
LIVER	HPS1 →	-0.999	-0.380	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PANK3 by Regulation of tetrapyrrole metabolic process activity — KIDNEY

Explore this box plot interactively →