Regulation of tetrapyrrole metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLYBL, SLC6A9, and PCK2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tetrapyrrole metabolic process activity versus CLYBL in KIDNEY (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CLYBL →	+1.204	+0.129	.002	.004	3	14
OVARY	SLC6A9 →	+1.737	+0.099	<.001	.007	2	13
CNS	PCK2 →	+1.012	+0.062	<.001	.005	3	9
BLOOD_Lymphoma	SIPA1L3 →	-1.550	-0.088	<.001	.002	3	8
BONE	RPS8 →	+0.698	+0.170	<.001	<.001	3	7
LARGE_INTESTINE	RPL10A →	+0.441	+0.069	.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901401 vs CLYBL — KIDNEY

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