Positive regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of voltage-gated calcium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, ITPR1, and RRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of voltage-gated calcium channel activity activity versus CLPX in LUAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CLPX →	-0.251	-0.041	.001	.002	3	6
UCEC	ITPR1 →	+0.264	+0.056	.003	<.001	3	6
OV	RRP1 →	-0.398	-0.045	<.001	.002	3	6
UCEC	SVIL_S644 →	+0.661	+0.057	<.001	<.001	3	5
HNSC	SYNPO →	+0.450	+0.057	<.001	.001	3	5
UCEC	ELMO2 →	+0.292	+0.066	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901387 vs CLPX — LUAD

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