Negative regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of voltage-gated calcium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMR1, TMOD1, and TMEM209, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of voltage-gated calcium channel activity activity versus FMR1 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FMR1 →	+0.597	+0.076	.001	.001	3	5
OV	TMOD1 →	-0.527	-0.073	.001	.002	3	5
BRCA	TMEM209 →	+0.270	+0.064	<.001	.004	3	4
HNSC	BCAP31 →	+0.428	+0.092	.001	<.001	3	4
BRCA	CLPTM1 →	+0.423	+0.073	.003	.002	2	5
HNSC	EIF5B_S137 →	+0.726	+0.092	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901386 vs FMR1 — OV

Explore this scatter interactively →