Negative regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TANK-AS1, MAP3K2-DT, and ACTG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of voltage-gated calcium channel activity activity versus TANK-AS1 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TANK-AS1 →	-0.406	-0.464	.004	.001	2	4
PDAC	MAP3K2-DT →	-0.228	-0.539	.007	.001	3	3
LSCC	ACTG2 →	-0.527	-0.517	.005	<.001	3	3
LSCC	MS4A4E →	-0.442	-0.532	.008	.003	3	3
LUAD	CARS1P2 →	-1.353	-0.348	<.001	.005	3	3
CCRCC	RN7SL418P →	-0.437	-0.550	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901386 vs TANK-AS1 — LUAD

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