Negative regulation of voltage-gated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of voltage-gated calcium channel activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNB5, DRD3, and CALM1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNB5 grouped by Negative regulation of voltage-gated calcium channel activity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNB5 →	-0.430	-1.615	<.001	.006	3	14
BREAST	DRD3 →	-0.267	-0.715	<.001	<.001	3	10
CNS	CALM1 →	-0.256	-0.988	<.001	.001	3	8
BLOOD_Myeloma	PKHD1 →	-0.325	-1.020	.007	.004	3	5
BONE	PRKCZ →	-0.214	-1.488	.001	.003	3	5
BREAST	DRD4 →	-0.146	-0.755	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNB5 by Negative regulation of voltage-gated calcium channel activity activity — LIVER

Explore this box plot interactively →