Negative regulation of voltage-gated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCRT, SURF1, and AP1S1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of voltage-gated calcium channel activity activity versus HCRT in LUNG_NSCLC_LUAD (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HCRT →	-0.080	-0.981	<.001	.005	3	2
LUNG_NSCLC_LUAD	SURF1 →	+0.838	+0.195	<.001	.003	2	2
LARGE_INTESTINE	AP1S1 →	-1.824	-1.478	.009	.003	2	1
LARGE_INTESTINE	CD1D →	-0.649	-1.475	.005	<.001	2	1
LUNG_NSCLC_LUAD	DNAH1 →	+0.885	+0.191	.001	.008	2	1
LUNG_NSCLC_LUAD	EEFSEC →	+0.644	+0.158	.008	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901386 vs HCRT — LUNG_NSCLC_LUAD

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