Negative regulation of potassium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK39, C16orf89, and ANK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of potassium ion transmembrane transport activity versus STK39 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STK39 →	+1.031	+0.215	<.001	<.001	3	7
UCEC	C16orf89 →	+1.485	+0.519	.002	.002	3	5
GBM	ANK3 →	+1.116	+1.003	<.001	<.001	3	5
LUAD	MYO9A →	+0.391	+0.171	<.001	.001	3	5
HNSC	CRYAB →	+1.222	+0.398	.001	.001	3	4
BRCA	CMA1 →	+0.836	+0.183	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901380 vs STK39 — BRCA

Explore this scatter interactively →