Negative regulation of potassium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV1, DRAP1, and FRMD6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of potassium ion transmembrane transport activity versus CAV1 in BREAST (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAV1 →	+5.975	+1.731	<.001	<.001	3	9
STOMACH	DRAP1 →	+1.630	+1.582	<.001	.007	2	7
LIVER	FRMD6 →	+3.296	+1.930	<.001	<.001	3	6
BREAST	CAV2 →	+4.455	+1.317	<.001	.002	3	6
OESOPHAGUS	ATP8A1 →	-0.990	-1.322	.003	.009	3	6
LUNG_NSCLC_LUSC	SERPINE1 →	+7.486	+2.118	.006	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901380 vs CAV1 — BREAST

Explore this scatter interactively →