Acetate ester transport

Across TCGA patient cohorts, RNA activity of the Acetate ester transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGXB4, AVP, and PLCB4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetate ester transport activity versus HMGXB4 in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HMGXB4 →	-0.288	-0.712	<.001	<.001	3	1
CCRCC	AVP →	+0.211	+0.435	.003	.005	3	1
CCRCC	PLCB4 →	-0.960	-0.588	.003	.004	3	1
CCRCC	NKAP →	-0.207	-0.596	.004	.004	3	1
CCRCC	SLC25A14 →	-0.206	-0.542	.006	.002	3	1
CCRCC	HTATSF1 →	-0.248	-0.612	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901374 vs HMGXB4 — CCRCC

Explore this scatter interactively →