Negative regulation of vasculature development

Across TCGA patient cohorts, RNA activity of the Negative regulation of vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD93, CRISPLD2, and PDGFRB, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vasculature development activity versus CD93 in TGCT (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	CD93 →	+1.725	+0.045	<.001	<.001	3	34
LIHC	CRISPLD2 →	+1.592	+0.032	<.001	<.001	3	33
CHOL	PDGFRB →	+2.014	+0.069	<.001	<.001	3	33
TGCT	NID1 →	+2.157	+0.042	<.001	<.001	3	33
MESO	TEK →	+1.534	+0.036	<.001	<.001	3	33
MESO	MYCT1 →	+1.534	+0.043	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901343 vs CD93 — TGCT

Explore this scatter interactively →