Negative regulation of vasculature development

Across TCGA cell cohorts, RNA activity of the Negative regulation of vasculature development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A1, PYROXD1, and PGK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A1 grouped by Negative regulation of vasculature development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	S100A1 →	-0.310	-0.847	<.001	<.001	3	5
SOFT_TISSUE	PYROXD1 →	-0.258	-0.674	<.001	.007	2	5
BLOOD_Myeloma	PGK1 →	-0.465	-1.480	.002	.004	3	4
SKIN	CAPN13 →	+0.196	+0.209	<.001	.003	3	4
OESOPHAGUS	SERPINE1 →	-0.131	-0.220	.008	.005	3	4
OESOPHAGUS	SOX3 →	-0.168	-0.243	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A1 by Negative regulation of vasculature development activity — SKIN

Explore this box plot interactively →