Positive regulation of store-operated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of store-operated calcium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO9B, NUDT6, and PLD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of store-operated calcium channel activity activity versus MYO9B in UCEC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO9B →	-0.325	-0.111	<.001	<.001	3	6
BRCA	NUDT6 →	+0.534	+0.060	<.001	<.001	3	5
COAD	PLD3 →	-0.196	-0.063	.007	<.001	3	5
LUAD	CPD →	+0.493	+0.065	.001	.001	3	4
BRCA	CAPZA1_T63 →	-0.782	-0.086	<.001	.002	3	4
BRCA	CARM1 →	-0.241	-0.039	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901341 vs MYO9B — UCEC

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