Positive regulation of store-operated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT2, TRMT10B, and BNIP3P40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of store-operated calcium channel activity activity versus SYT2 in GBM (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT2 →	-0.512	-0.783	.002	<.001	3	4
PDAC	TRMT10B →	-0.283	-0.462	.001	.005	3	4
PDAC	BNIP3P40 →	-0.245	-0.361	.009	.007	3	4
BRCA	KANSL1L-AS1 →	-0.354	-0.645	.001	.002	3	4
BRCA	ADAM22 →	-0.545	-0.622	.001	.002	3	4
GBM	DPYSL2 →	-0.304	-0.548	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901341 vs SYT2 — GBM

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