Positive regulation of store-operated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFS2, ITGB1, and ISYNA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of store-operated calcium channel activity activity versus NDUFS2 in BONE (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NDUFS2 →	-1.229	-1.953	.002	<.001	3	6
BONE	ITGB1 →	+2.069	+1.504	.004	.006	3	6
BONE	ISYNA1 →	-3.463	-1.620	<.001	<.001	3	5
BONE	SALL2 →	-4.886	-1.851	<.001	<.001	3	5
BONE	PSORS1C1 →	+2.105	+1.988	<.001	<.001	3	5
OVARY	WDCP →	-0.875	-0.385	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901341 vs NDUFS2 — BONE

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