Regulation of store-operated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of store-operated calcium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STIM2, CEBPZ, and CPSF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of store-operated calcium channel activity activity versus STIM2 in LSCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STIM2 →	+0.356	+0.089	<.001	<.001	3	6
LSCC	CEBPZ →	-0.215	-0.056	.008	<.001	3	5
CCRCC	CPSF1 →	-0.073	-0.050	.007	.004	3	5
UCEC	HEATR1 →	-0.265	-0.082	.002	.002	3	5
OV	STIM1 →	+0.559	+0.077	<.001	<.001	3	5
UCEC	RTF2 →	-0.275	-0.084	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901339 vs STIM2 — LSCC

Explore this scatter interactively →