Regulation of store-operated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF8, SYT2, and ARPC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of store-operated calcium channel activity activity versus KLF8 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLF8 →	-0.525	-0.353	.004	.004	3	4
GBM	SYT2 →	-0.542	-0.313	.001	.001	3	4
BRCA	ARPC3 →	+0.321	+0.676	.006	<.001	3	3
CCRCC	ZBTB21 →	-0.241	-0.477	.005	.001	3	3
CCRCC	PSMB8 →	+0.363	+0.712	<.001	<.001	3	3
LSCC	MIR17HG →	-0.687	-0.252	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901339 vs KLF8 — LUAD

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