Regulation of store-operated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANS, GIPC1, and DOLPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NANS grouped by Regulation of store-operated calcium channel activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NANS →	-1.236	-1.602	<.001	<.001	3	4
OESOPHAGUS	GIPC1 →	-0.673	-1.325	<.001	<.001	3	4
KIDNEY	DOLPP1 →	-0.798	-1.168	<.001	<.001	3	4
KIDNEY	UVRAG →	-0.900	-1.179	.006	.005	3	4
SKIN	RAB36 →	-1.097	-1.292	.001	<.001	3	4
PANCREAS	TRPC1 →	-1.343	-1.224	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NANS by Regulation of store-operated calcium channel activity activity — KIDNEY

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