Regulation of store-operated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPZ2, TCTN1, and STIM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of store-operated calcium channel activity activity versus COPZ2 in CNS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	COPZ2 →	+1.719	+0.203	.002	<.001	3	5
PANCREAS	TCTN1 →	+0.806	+0.178	.004	.003	2	6
BREAST	STIM1 →	+1.186	+0.403	<.001	.002	3	5
BLOOD_Myeloma	DCTN6 →	+1.055	+0.417	<.001	.002	3	4
CNS	POLK →	+0.654	+0.179	<.001	.002	3	4
CNS	NNMT →	+2.478	+0.281	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901339 vs COPZ2 — CNS

Explore this scatter interactively →