Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXP1, NEK7, and ITPRIPL2, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide-mediated programmed cell death activity versus FOXP1 in THYM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FOXP1 →	+0.829	+0.070	<.001	<.001	3	24
THYM	NEK7 →	+0.950	+0.056	<.001	<.001	3	23
THYM	ITPRIPL2 →	+1.665	+0.056	<.001	<.001	3	22
THYM	GNG12-AS1 →	+0.583	+0.067	<.001	<.001	3	22
THYM	TRIO →	+1.116	+0.066	<.001	<.001	3	21
ACC	BBS9 →	+0.649	+0.058	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901298 vs FOXP1 — THYM

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