Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, SEPTIN4_S432, and SEPTIN8, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide-mediated programmed cell death activity versus ARHGEF17 in CCRCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGEF17 →	+0.390	+0.068	<.001	<.001	3	9
LUAD	SEPTIN4_S432 →	+0.679	+0.058	<.001	<.001	3	8
CCRCC	SEPTIN8 →	+0.296	+0.067	<.001	<.001	3	8
CCRCC	TNS2 →	+0.415	+0.070	<.001	<.001	3	8
PDAC	TNS2_S120 →	+0.530	+0.068	<.001	<.001	3	8
COAD	VCL →	+0.415	+0.026	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901298 vs ARHGEF17 — CCRCC

Explore this scatter interactively →