Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA patient cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFAP5, KRAS, and GADL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide-mediated programmed cell death activity versus MFAP5 in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFAP5 →	+1.559	+0.709	.001	.004	3	3
BRCA	KRAS →	+0.439	+0.356	.006	.009	3	2
BRCA	GADL1 →	-0.033	-0.500	.002	.001	3	2
BRCA	EDIL3 →	+0.882	+0.360	.003	.004	3	2
LSCC	ESYT2 →	+0.402	+0.448	.005	.003	3	2
LSCC	SLC37A3 →	+0.353	+0.302	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901298 vs MFAP5 — UCEC

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