Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA cell cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM1, CCDC112, and EPB41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPM1 grouped by Regulation of hydrogen peroxide-mediated programmed cell death-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NPM1 →	-0.973	-0.375	<.001	<.001	3	4
KIDNEY	CCDC112 →	-0.596	-0.906	.001	.002	3	3
OVARY	EPB41 →	+0.876	+0.671	.002	.004	3	3
OVARY	ERO1B →	+0.860	+0.691	<.001	.003	3	3
LARGE_INTESTINE	TBC1D16 →	+0.893	+0.251	.003	.001	3	3
LUNG_NSCLC_LUAD	HDAC3 →	-0.457	-0.561	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPM1 by Regulation of hydrogen peroxide-mediated programmed cell death activity — LUNG_SCLC

Explore this box plot interactively →