Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA cell cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDA, PINK1, and PLEKHN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide-mediated programmed cell death activity versus CDA in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CDA →	+2.875	+0.132	<.001	<.001	3	10
URINARY_TRACT	PINK1 →	+0.963	+0.114	.006	<.001	3	10
LIVER	PLEKHN1 →	+1.087	+0.143	.009	.003	3	9
BREAST	PSORS1C1 →	+1.086	+0.074	.007	.002	2	9
OESOPHAGUS	PADI1 →	+2.243	+0.104	<.001	<.001	3	7
KIDNEY	PAWR →	+1.409	+0.144	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901298 vs CDA — UPPER_AERODIGESTIVE_TRACT

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