Regulation of hydrogen peroxide-mediated programmed cell death

Across TCGA cell cohorts, RNA activity of the Regulation of hydrogen peroxide-mediated programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJA3, KRT18, and PLS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hydrogen peroxide-mediated programmed cell death activity versus DNAJA3 in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DNAJA3 →	+0.658	+0.206	.002	.003	3	8
LUNG_SCLC	KRT18 →	-3.389	-0.175	.007	.007	3	6
LUNG_NSCLC_LUAD	PLS3 →	-0.783	-0.132	.003	.003	2	7
BLOOD_Leukemia	TRAP1 →	+0.672	+0.129	.001	<.001	3	6
LIVER	EPB41 →	+1.221	+0.258	.001	.001	3	6
PANCREAS	SLC5A6 →	+0.741	+0.202	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901298 vs DNAJA3 — LIVER

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