Nucleoside phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM17_S169, WNK2_S1862, and SLC12A7_T973, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate biosynthetic process activity versus RBM17_S169 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBM17_S169 →	+0.635	+0.025	.001	<.001	3	5
LUAD	WNK2_S1862 →	+0.690	+0.014	.003	.005	3	5
LSCC	SLC12A7_T973 →	+0.714	+0.024	.001	<.001	3	4
LSCC	EXOC7_S283 →	+0.527	+0.021	.001	<.001	3	4
LSCC	MAT1A →	+0.527	+0.013	.006	.009	3	4
LSCC	NAA16 →	-0.267	-0.020	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901293 vs RBM17_S169 — LSCC

Explore this scatter interactively →