Nucleoside phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIPAS39, ATP10D, and TRIAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VIPAS39 grouped by Nucleoside phosphate biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VIPAS39 →	-0.827	-0.209	.001	.001	3	5
BREAST	ATP10D →	-0.941	-0.168	.001	<.001	3	5
OVARY	TRIAP1 →	+0.723	+0.250	.007	<.001	2	5
BREAST	TRIP10 →	-0.892	-0.205	.001	.001	3	4
LARGE_INTESTINE	TCP11L2 →	-0.744	-0.126	<.001	.007	3	4
SOFT_TISSUE	SLC44A2 →	+1.630	+0.137	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VIPAS39 by Nucleoside phosphate biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →