Nucleoside phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NDUFA2, NDUFA7, and NDUFS6, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate biosynthetic process activity versus NDUFA2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NDUFA2 →	+0.905	+0.271	<.001	<.001	3	18
BREAST	NDUFA7 →	+1.214	+0.195	<.001	<.001	3	17
LUNG_NSCLC_LUAD	NDUFS6 →	+1.113	+0.252	<.001	<.001	3	17
PANCREAS	NDUFV2 →	+1.069	+0.295	<.001	<.001	3	16
BREAST	NDUFB1 →	+1.015	+0.184	<.001	<.001	3	16
PANCREAS	NDUFS1 →	+0.976	+0.303	.003	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901293 vs NDUFA2 — UPPER_AERODIGESTIVE_TRACT

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