Nucleoside phosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside phosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FXR1, RUNX1_T14, and ITSN1_S978, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate catabolic process activity versus FXR1 in OV (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FXR1 →	-0.257	-0.024	.009	.002	3	5
GBM	RUNX1_T14 →	-0.595	-0.031	.004	.006	3	5
BRCA	ITSN1_S978 →	+0.838	+0.029	<.001	<.001	3	5
UCEC	PPP1R3E_S33 →	+0.873	+0.072	<.001	<.001	3	5
GBM	SEPTIN4 →	+0.764	+0.042	<.001	<.001	3	5
GBM	TOP1 →	-0.270	-0.033	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901292 vs FXR1 — OV

Explore this scatter interactively →