Nucleoside phosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside phosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR2, ITGAM, and CSF1R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate catabolic process activity versus TLR2 in COAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLR2 →	+0.781	+0.125	.003	.004	3	6
COAD	ITGAM →	+0.881	+0.116	<.001	.001	3	6
LSCC	CSF1R →	+0.643	+0.171	.002	.002	3	6
LSCC	RASGRP4 →	+0.260	+0.121	.005	.007	3	6
OV	COX7B →	-0.664	-0.113	.003	.008	3	5
COAD	SLC7A7 →	+0.785	+0.142	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901292 vs TLR2 — COAD

Explore this scatter interactively →