Nucleoside phosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPPED1, CREB3, and GPR68, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPPED1 grouped by Nucleoside phosphate catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CPPED1 →	-0.173	-0.731	<.001	.003	3	4
SKIN	CREB3 →	-0.106	-0.689	.006	.007	3	3
LUNG_NSCLC_LUAD	GPR68 →	-0.129	-0.143	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MRAP2 →	-0.163	-0.121	.002	<.001	3	3
KIDNEY	SMAD2 →	-0.218	-0.184	<.001	<.001	2	4
BLOOD_Myeloma	ADPGK →	-0.273	-0.192	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPPED1 by Nucleoside phosphate catabolic process activity — SKIN

Explore this box plot interactively →