Nucleoside phosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCALD, ANLN, and SLC25A37, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCALD grouped by Nucleoside phosphate catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NCALD →	-2.135	-0.202	.001	<.001	3	6
STOMACH	ANLN →	+1.536	+0.233	.008	.007	3	5
STOMACH	SLC25A37 →	+1.071	+0.190	.004	.001	3	5
STOMACH	COQ8A →	-1.256	-0.214	.001	.009	3	5
LUNG_NSCLC_LUSC	AXL →	+6.061	+0.345	<.001	.006	2	6
STOMACH	SNTB1 →	-2.567	-0.169	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCALD by Nucleoside phosphate catabolic process activity — OVARY

Explore this box plot interactively →