Nucleoside phosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHACTR3, ANXA9, and PIP4K2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate catabolic process activity versus PHACTR3 in LARGE_INTESTINE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHACTR3 →	-1.484	-0.240	.008	.001	3	6
LUNG_NSCLC_LUAD	ANXA9 →	-1.880	-0.177	<.001	.002	3	6
LUNG_NSCLC_LUSC	PIP4K2A →	+1.240	+0.354	<.001	.001	2	7
LARGE_INTESTINE	SAP30 →	+1.055	+0.209	.001	.009	3	6
URINARY_TRACT	CDH3 →	-5.844	-0.678	.001	.004	3	6
LUNG_NSCLC_LUAD	ZEB1 →	+1.344	+0.191	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901292 vs PHACTR3 — LARGE_INTESTINE

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