Succinyl-CoA catabolic process

Across TCGA patient cohorts, RNA activity of the Succinyl-CoA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRPPRC, SH3BGRL, and CLUH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA catabolic process activity versus LRPPRC in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LRPPRC →	+0.438	+0.056	<.001	.001	3	7
LSCC	SH3BGRL →	-0.364	-0.079	.002	<.001	3	7
BRCA	CLUH →	+0.354	+0.069	<.001	<.001	3	7
LSCC	DDX21 →	+0.493	+0.081	<.001	<.001	3	6
LSCC	SLIRP →	+0.415	+0.087	<.001	<.001	3	6
BRCA	BZW2 →	+0.395	+0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901289 vs LRPPRC — LUAD

Explore this scatter interactively →