Succinyl-CoA catabolic process

Across TCGA patient cohorts, RNA activity of the Succinyl-CoA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUDT19, TIMM23, and HSPD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA catabolic process activity versus NUDT19 in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NUDT19 →	+0.579	+0.125	<.001	<.001	3	7
HNSC	TIMM23 →	+0.415	+0.149	<.001	<.001	3	4
OV	HSPD1 →	+0.644	+0.140	<.001	<.001	3	4
HNSC	MCCC1 →	+0.465	+0.118	.001	<.001	3	4
OV	MCCC2 →	+0.622	+0.124	<.001	.001	3	4
GBM	NUDT8 →	+0.642	+0.093	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901289 vs NUDT19 — OV

Explore this scatter interactively →