Succinyl-CoA catabolic process

Across TCGA cell cohorts, RNA activity of the Succinyl-CoA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ULK3, VPS36, and NINJ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA catabolic process activity versus ULK3 in OESOPHAGUS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ULK3 →	+1.218	+0.184	.001	.005	3	5
SKIN	VPS36 →	+0.705	+0.209	.001	.002	3	5
OESOPHAGUS	NINJ1 →	+0.892	+0.167	.002	.001	3	4
BLOOD_Lymphoma	SKOR1 →	+0.256	+0.167	.001	<.001	2	5
OVARY	ECH1 →	+1.399	+0.262	.001	<.001	3	4
BONE	AP4B1 →	-1.314	-0.404	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901289 vs ULK3 — OESOPHAGUS

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