Positive regulation of non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLFN5, PLAAT4, and GIMAP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of non-canonical NF-kappaB signal transduction activity versus SLFN5 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLFN5 →	+0.776	+0.141	<.001	<.001	3	5
LSCC	PLAAT4 →	+0.980	+0.102	.001	.001	3	5
LSCC	GIMAP5 →	+0.627	+0.109	<.001	<.001	3	5
LUAD	STS →	+0.598	+0.109	.001	<.001	3	4
GBM	SOX4 →	-1.008	-0.140	.001	.003	3	4
LSCC	FAM136A →	-0.466	-0.097	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901224 vs SLFN5 — BRCA

Explore this scatter interactively →