Positive regulation of non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP14, IFI35, and DHX58, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of non-canonical NF-kappaB signal transduction activity versus PARP14 in BONE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PARP14 →	-2.947	-0.229	.001	.002	3	6
LUNG_SCLC	IFI35 →	-2.390	-0.187	<.001	.001	3	6
LUNG_NSCLC_LUAD	DHX58 →	-1.640	-0.248	.002	<.001	2	7
UPPER_AERODIGESTIVE_TRACT	GABARAP →	+0.968	+0.254	<.001	.007	3	5
BONE	OAS3 →	-2.663	-0.231	.004	.001	3	5
LUNG_SCLC	NFKBIZ →	-1.355	-0.175	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901224 vs PARP14 — BONE

Explore this scatter interactively →