Negative regulation of non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RA, TMEM52B, and CEACAM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of non-canonical NF-kappaB signal transduction activity versus CSF2RA in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSF2RA →	+0.970	+0.207	<.001	<.001	3	6
LSCC	TMEM52B →	+0.937	+0.178	<.001	.005	3	5
LSCC	CEACAM4 →	+0.621	+0.156	<.001	<.001	3	5
UCEC	FGD2 →	+0.688	+0.180	<.001	.001	3	5
LSCC	SHISAL2A →	+0.630	+0.230	<.001	<.001	3	5
BRCA	SERPINF1 →	+1.081	+0.336	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901223 vs CSF2RA — UCEC

Explore this scatter interactively →