Negative regulation of non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3D, LEPROTL1, and SNRPA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3D grouped by Negative regulation of non-canonical NF-kappaB signal transduction-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	POLR3D →	+1.313	+2.006	<.001	<.001	3	4
BLOOD_Lymphoma	LEPROTL1 →	+1.237	+1.411	.001	.005	3	4
LUNG_NSCLC_LUAD	SNRPA1 →	+0.427	+0.445	.007	.004	3	4
SOFT_TISSUE	SCARA3 →	-2.685	-0.644	<.001	.008	2	4
PANCREAS	CCDC106 →	-1.840	-0.856	.002	.005	3	3
STOMACH	DVL1 →	+0.577	+1.211	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3D by Negative regulation of non-canonical NF-kappaB signal transduction activity — BLOOD_Lymphoma

Explore this box plot interactively →