Negative regulation of non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASCC1, CPNE1, and PSMA7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of non-canonical NF-kappaB signal transduction activity versus ASCC1 in OVARY (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASCC1 →	-1.010	-1.061	<.001	<.001	3	4
OVARY	CPNE1 →	+1.702	+1.201	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PSMA7 →	+0.725	+0.895	.004	<.001	3	4
PANCREAS	IFT57 →	+1.764	+1.077	.009	.007	3	4
LUNG_NSCLC_LUAD	STAU1 →	+0.510	+0.875	.006	<.001	3	4
SKIN	CTNNBL1 →	+0.668	+0.790	.002	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901223 vs ASCC1 — OVARY

Explore this scatter interactively →