Regulation of non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP9, RAD51C, and ZDHHC23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKAP9 grouped by Regulation of non-canonical NF-kappaB signal transduction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AKAP9 →	+0.941	+0.141	.003	.006	2	5
LIVER	RAD51C →	-0.821	-0.189	.001	.001	3	4
URINARY_TRACT	ZDHHC23 →	+2.580	+0.461	.004	.004	3	3
SKIN	MDM2 →	+0.952	+0.142	.006	.001	2	4
SKIN	STT3B →	+0.526	+0.169	.007	.002	3	3
BLOOD_Lymphoma	ERMN →	+0.973	+0.318	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKAP9 by Regulation of non-canonical NF-kappaB signal transduction activity — OVARY

Explore this box plot interactively →