Positive regulation of extracellular matrix assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEG1, ITPRIPL2, and BTBD7, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extracellular matrix assembly activity versus HEG1 in SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	HEG1 →	+1.607	+0.139	<.001	<.001	3	33
THYM	ITPRIPL2 →	+1.769	+0.058	<.001	<.001	3	33
UVM	BTBD7 →	+0.942	+0.058	<.001	<.001	3	32
UVM	SOS1 →	+1.464	+0.056	<.001	<.001	3	32
DLBC	MED13L →	+1.445	+0.050	<.001	.001	3	32
CHOL	TLN1 →	+1.307	+0.109	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901203 vs HEG1 — SCLC

Explore this scatter interactively →