Positive regulation of extracellular matrix assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of extracellular matrix assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN7, SVIL, and TIMP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extracellular matrix assembly activity versus SEPTIN7 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN7 →	+0.256	+0.091	<.001	<.001	3	9
UCEC	SVIL →	+0.590	+0.111	<.001	<.001	3	9
BRCA	TIMP2 →	+0.673	+0.064	<.001	<.001	3	9
OV	ACTN1 →	+0.606	+0.096	<.001	<.001	3	9
UCEC	VCL →	+0.552	+0.090	<.001	<.001	3	9
UCEC	CSRP1 →	+0.947	+0.097	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901203 vs SEPTIN7 — UCEC

Explore this scatter interactively →